Overview
In the injured central nervous system (CNS), reactive astrocytes form a glial scar and are considered to be detrimental for axonal regeneration, but their function remains elusive. The current protocol demonstrates that reactive astrocytes play a crucial role in wound healing and functional recovery by using mice with a selective deletion of the signal transducer and activator of transcription-3 (STAT3) or suppression of cytokine signaling-3 (SOCS3) under the control of Nestin gene promoter/enhancer (STAT3N–/–, SOCS3N–/–). By Seiji Okada
Details
Details of this protocol, Conditional Ablation Of Stat3/socs3 Discloses The Dual Role For Reactive Astrocytes After Spinal Cord Injury, are located on a web site other than Biocompare Protocols.