Overview
Amplification of cosmid libraries may result in distorted representation of cloned genomic sequences and should be avoided wherever possible. In this method of amplification, distortion of the library is rarely a problem because at no stage are bacteria containing different recombinant cosmids grown in competition with one another. The major problem with this method is its tediousness. By Joseph Sambrook and David W. Russell.
Details
Details of this protocol, Amplification And Storage Of A Cosmid Library: Amplification On Filters (Subscription Required), are located on a web site other than Biocompare Protocols.