Overview
Amplification of cosmid libraries may result in distorted representation of cloned genomic sequences and should be avoided wherever possible. If amplification should become necessary, it is best to expand the library by growth in liquid medium, as described here. By Joseph Sambrook and David W. Russell.
Details
Details of this protocol, Amplification And Storage Of A Cosmid Library: Amplification In Liquid Culture (Subscription Required), are located on a web site other than Biocompare Protocols.